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Updated: Jun 9, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
Published on: January 19, 2024
Anemia in older persons.
Michael H Bross1, Kathleen Soch, Teresa Smith-Knuppel
1University of Colorado Denver School of Medicine, Aurora, Colorado, USA. michael.bross@ucdenver.edu
Anemia in older adults is often missed but linked to worse health outcomes. Evaluation is crucial, as causes range from nutritional deficiencies to chronic diseases, with varying treatment effectiveness.
Area of Science:
- Gerontology
- Hematology
- Internal Medicine
Background:
- Anemia in older adults (hemoglobin <13g/dL men, <12g/dL women) affects over 10% of those >65.
- Prevalence increases with age, reaching 50% in nursing home residents.
- Even mild anemia is linked to increased morbidity and mortality.
Purpose of the Study:
- To highlight the significance of anemia in older persons.
- To discuss the prevalence, causes, and management of anemia in this demographic.
- To emphasize the need for evaluation and appropriate interventions.
Main Methods:
- Review of World Health Organization definition of anemia.
- Categorization of anemia causes: nutritional deficiency, chronic inflammation/kidney disease, unexplained.
- Discussion of treatment strategies for different anemia types.
Main Results:
- Approximately one-third of anemia cases are due to nutritional deficiencies.
- Another third result from chronic inflammation or chronic kidney disease.
- The remaining third are unexplained, posing treatment challenges.
Conclusions:
- Anemia evaluation is recommended for most older individuals.
- Nutritional anemias are treatable with replacement therapy.
- Anemia of chronic disease/kidney disease may improve with underlying condition management and erythropoiesis-stimulating agents.
- Treatment for unexplained anemia lacks strong evidence for improving outcomes or quality of life.
- Less common causes like autoimmune hemolytic anemia, malignancy, or myelodysplastic syndrome require specific investigation.
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