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Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
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Published on: March 1, 2022

[Functional glutamate signaling in bone].

Eiichi Hinoi1

  • 1Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Ishikawa, Japan. hinoi@p.kanazawa-u.ac.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|September 9, 2010
PubMed
Summary
This summary is machine-generated.

L-glutamate (Glu) acts as an extracellular signal in bone, influencing osteoblast differentiation and inhibiting osteoclast formation. This suggests Glu plays a key role in maintaining bone homeostasis.

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Area of Science:

  • Neuroscience
  • Bone Biology
  • Cellular Signaling

Context:

  • L-glutamate (Glu) is primarily known as a central nervous system neurotransmitter.
  • Its role in peripheral tissues, specifically bone, is less understood.
  • This review focuses on Glu's function in bone cellular homeostasis.

Purpose:

  • To summarize the signaling mechanisms of Glu in bone tissues.
  • To investigate the expression and function of Glu receptors and transporters in osteoblasts and osteoclasts.
  • To evaluate Glu's effect on bone cell differentiation and bone mineral density.

Summary:

  • Osteoblasts express Glu receptors (GluR) and transporters (GluT); blocking N-methyl-D-aspartic acid receptors impairs osteoblast differentiation.
  • Osteoclasts express GluT, and Glu inhibits osteoclastogenesis.
  • [3H]Glu uptake in osteoblasts resembles brain GluT profiles.
  • Systemic Glu administration in ovariectomized mice improved bone mineral density and reduced osteoclast indices.

Impact:

  • L-glutamate emerges as a significant extracellular mediator in bone.
  • Findings suggest novel therapeutic targets for bone diseases.
  • Highlights the importance of exploring neurotransmitter roles in non-neuronal tissues.