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Attrition in a multicenter clinical trial for panic disorder.
Kamila S White1, Laura B Allen, David H Barlow
1Department of Psychology, University of Missouri-Saint Louis, Saint Louis, MO 63121, USA. whiteks@umsl.edu
The Journal of Nervous and Mental Disease
|September 9, 2010
Summary
This study found that patient attrition in panic disorder clinical trials is low, with younger age being the only significant predictor. These findings suggest that attrition is unlikely to compromise the validity of treatment outcome studies.
Area of Science:
- Psychiatry
- Clinical Psychology
- Medical Research
Background:
- Patient attrition is a significant concern in clinical trials, potentially impacting study validity.
- Understanding factors associated with attrition is crucial for improving trial design and patient retention.
Purpose of the Study:
- To examine attrition rates and identify predictors in a multisite clinical trial for panic disorder.
- To assess the impact of demographic, diagnostic, and treatment-related factors on patient attrition.
Main Methods:
- Logistic regression analysis was employed to investigate factors associated with attrition.
- Data were analyzed from 379 eligible patients in a panic disorder clinical trial.
Main Results:
- The overall attrition rate was 32% (19% dropout, 8% withdrawal), with a 68% completion rate.
- Younger age was the sole independent predictor of attrition.
- Diagnostic severity, symptom severity, and treatment/therapist factors did not significantly predict attrition.
- Patient dropout was highest following sessions involving interoceptive and situational exposure therapy.
Conclusions:
- Attrition rates in this panic disorder trial were relatively low.
- Younger age is a key demographic factor associated with attrition.
- Attrition is unlikely to pose a significant threat to the validity of findings in panic disorder treatment outcome studies.
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