Development of 5-silylethynyl-1,3-dioxolan-4-one as a new prochiral template for asymmetric phase-transfer catalysis
Takuya Hashimoto1, Kazuhiro Fukumoto, Naoyuki Abe
1Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Chemical Communications (Cambridge, England)
|September 11, 2010
Abstract:
Phase-transfer catalyzed asymmetric alkylation and Michael addition of 5-silylalkynyl-1,3-dioxolan-4-one were developed as a novel strategy to provide highly modular tertiary α-alkyl-α-hydroxy acids bearing an alkyne moiety.
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