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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Methods: genetic epidemiology.

Kelly S Benke1, M Daniele Fallin

  • 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, W6033, Baltimore, MD 21205, USA.

Clinics in Laboratory Medicine
|September 14, 2010
PubMed
Summary
This summary is machine-generated.

Genetic epidemiology is key for psychiatric gene discovery. This review covers tools and methods, focusing on genome-wide association studies, and discusses future challenges.

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Area of Science:

  • Psychiatric genetics
  • Genetic epidemiology
  • Genomic association studies

Background:

  • Gene identification offers significant benefits for understanding psychiatric disorders.
  • Genetic epidemiology has emerged as a crucial discipline in psychiatric research.
  • Advances in genetic research necessitate a review of current methodologies.

Purpose of the Study:

  • To discuss the primary tools and methodologies used in psychiatric gene discovery.
  • To focus on the designs and analytical approaches of genetic association studies, particularly genome-wide association studies (GWAS).
  • To highlight current challenges in genetic epidemiology and anticipate future research directions for psychiatric disorders.

Main Methods:

  • Review of established and emerging techniques for gene discovery in psychiatry.
  • Detailed examination of study designs and analytical strategies for genetic association studies.
  • Emphasis on genome-wide association studies (GWAS) as the predominant method.

Main Results:

  • Genetic association studies, especially GWAS, are the leading methods for gene discovery in psychiatry.
  • The article provides a comprehensive overview of the methodologies employed in these studies.
  • Current limitations and challenges within genetic epidemiology are identified.

Conclusions:

  • Genome-wide association studies are central to current psychiatric gene discovery efforts.
  • Addressing the challenges in genetic epidemiology is essential for advancing research into psychiatric disorders.
  • Future approaches will likely build upon GWAS and incorporate novel strategies to overcome existing hurdles.