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Updated: Jun 8, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Liquiritigenin derivatives and their hepatotoprotective activity
Rashmi Gaur1, Sunil Kumar, Priyanka Trivedi
1Central Institute of Medicinal and Aromatic Plants, P.O. CIMAP, Lucknow 226015, India.
Abstract:
Liquiritigenin (7,4'-dihydroxyflavanone), isolated from the roots of Glycyrrhiza glabra, was derivatized to liquiritigenin 7, 4'-diacetate, liquiritigenin 4'-acetate, isoliquiritigenin, and liquiritigenin 7, 4'-dibenzoate. All these derivatives were evaluated for in vitro hepatoprotective activity against D-galactosamine-lipopolysaccharide(GalN/LPS) induced toxicity. In-vitro hepatotoxicity was manifested by a significant increase (P < 0.05) in liver toxicity biomarkers (SGPT, SGOT, ALKP, triglyceride, LPO, NO and LDH). The level of biomarkers in the treatment groups was significantly decreased (P < 0.05) when compared with the GalN/LPS group. The results revealed that isoliquiritigenin exhibited better hepatoprotective activity than liquiritigenin and its derivatives.
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