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Coronary artery disease associated with aortitis syndrome in older patients
S Morooka1, T Hayashi, K Takayanagi
1Department of Cardiology, Koshigaya Hospital, Dokkyo University, School of Medicine, Saitama, Japan.
Insights
Coronary artery disease is present in 21% of patients with aortitis syndrome, often appearing after middle age. Lesions include ostial stenosis from aortitis and main branch stenosis from arteriosclerosis.
Area of Science:
- Cardiovascular Medicine
- Rheumatology
- Vascular Biology
Background:
- Aortitis syndrome, an inflammatory condition affecting the aorta, can have systemic implications.
- Coronary artery disease (CAD) is a significant cause of morbidity and mortality.
- The relationship between aortitis syndrome and CAD, particularly the characteristics of coronary lesions, requires further investigation.
Purpose of the Study:
- To investigate the prevalence and characteristics of coronary artery disease in patients with aortitis syndrome.
- To analyze the types of coronary artery lesions and their association with patient age and underlying aortitis.
Main Methods:
- Retrospective analysis of 19 patients diagnosed with aortitis syndrome.
- Evaluation of coronary artery lesions through angiography.
- Correlation of lesion types with patient demographics and clinical presentation.
Main Results:
- Four out of 19 patients (21%) with aortitis syndrome exhibited coronary artery disease.
- The mean age of affected patients was 53 ± 14 years.
- Observed coronary lesions included isolated ostial stenosis (n=2) and isolated main branch stenosis (n=2), with the latter group being older and showing signs of arteriosclerosis, and one patient had severe coarctation of the aorta.
Conclusions:
- Coronary artery disease may not be uncommon in patients with aortitis syndrome, especially after middle age.
- Coronary ostial stenosis in this cohort is likely related to the aortitis itself.
- Coronary main branch stenosis appears to be associated with secondary arteriosclerosis, with onset typically occurring after middle age.
Abstract:
Coronary artery disease associated with aortitis syndrome was studied in relation to the coronary artery lesions and age. Four (21%) of 19 patients with aortitis syndrome had coronary artery disease and the mean age of the 4 patients was 53 +/- 14 years. The coronary artery lesions included ostial stenosis in 2 patients and main branch stenosis in 2, but both types of lesion were isolated. The latter patients were older and had coronary lesions like arteriosclerosis on angiogram. Myocardial infarction and congestive heart failure were not present, but a severe coarctation of the aorta was observed in the latter. It was suggested that coronary artery disease might not be rare past middle age, and might include coronary ostial stenosis caused by aortitis and coronary main branch stenosis probably based on secondary arteriosclerosis whose onset was past middle age.