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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Proteinuria in children.

Alexander K C Leung1, Alex H C Wong

  • 1University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. aleung@ucalgary.ca

American Family Physician
|September 17, 2010
PubMed
Summary
This summary is machine-generated.

Proteinuria in children can be benign or indicate serious kidney disease. A first-morning urine protein/creatinine ratio test is a practical alternative to 24-hour urine collection for diagnosis.

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Area of Science:

  • Pediatric Nephrology
  • Clinical Diagnostics

Background:

  • Proteinuria is a common finding in pediatric patients.
  • It can range from benign conditions to indicators of significant renal or systemic diseases.
  • Causes include glomerular or tubular dysfunction.

Purpose of the Study:

  • To highlight the diagnostic utility of the urine protein/creatinine ratio in pediatric proteinuria.
  • To differentiate between benign and serious causes of proteinuria in children.

Main Methods:

  • Review of clinical features, history, physical examination, and laboratory tests.
  • Evaluation of the protein/creatinine ratio as a diagnostic tool.
  • Consideration of renal biopsy and specialist referral criteria.

Main Results:

  • Transient or orthostatic proteinuria are typically benign.
  • Persistent proteinuria may signify underlying renal pathology.
  • The protein/creatinine ratio offers a practical alternative to 24-hour urine protein excretion in children.

Conclusions:

  • Prompt identification of proteinuria causes is crucial for appropriate management.
  • Clinical assessment guides the need for further investigations like renal biopsy.
  • Management should target the specific underlying etiology of pediatric proteinuria.