Related Experiment Video
Updated: Jun 8, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
[Care for patients on mechanical ventilation from the perspective of an internal medicine physician]
Y Stanková1, P Stourac, J Skricková
1Klinika nemocí plicních a tuberkulózy Lékarské fakulty MU a FN Brno. yvastankova@centrum.cz
Abstract:
At times of respiratory insufficiency, mechanical ventilation (MV) provides support for or a substitution ofcertain components of the respiratory system. The aim of ventilation therapy is to achieve appropriate ventilation and oxygenation parameters and to minimize adverse events of MV. The main examples of non-invasive ventilation (NIV) are Continuous Positive Airway Pressure (CPAP) and Bi-level Positive Airway Pressure (BiPAP). The main benefit of NIV is a minimal need for tracheal intubation. To perform invasive mechanical ventilation, it is necessary to secure the airways with intubation or tracheotomy. We aim for the shortest possible duration of mechanical ventilation and intubation; their duration is a risk factor in development of ventilator-associated pneumonia.
Related Concept Videos
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...

