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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Relationship between aortic valve calcification and the severity of coronary atherosclerotic disease

Juying Qian1, Zhangwei Chen, Junbo Ge

  • 1Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.

The Journal of Heart Valve Disease
|September 18, 2010
PubMed

Insights

Aortic valve calcification (AVC) is more common in patients with coronary artery disease (CAD). This study found AVC is linked to a higher prevalence and severity of CAD in elderly patients.

Area of Science:

  • Cardiology
  • Geriatrics
  • Diagnostic Imaging

Background:

  • Aortic valve calcification (AVC) is prevalent in the elderly and linked to cardiovascular mortality.
  • AVC is hypothesized to correlate with coronary atherosclerotic disease (CAD) and its severity.

Purpose of the Study:

  • To investigate the association between aortic valve calcification (AVC) and the prevalence and severity of coronary atherosclerotic disease (CAD).

Main Methods:

  • Coronary angiography was performed on 235 patients presenting with chest pain.
  • Coronary artery disease (CAD) severity was assessed using the Gensini score, number of stenosed vessels, and total occlusion.
  • Transthoracic echocardiography was used to detect aortic valve calcification (AVC).

Main Results:

  • Patients with CAD showed a higher prevalence of AVC (44%) compared to those without CAD (26%).
  • AVC prevalence increased with higher Gensini scores, indicating more severe CAD.
  • Multivariable analysis revealed AVC as an independent predictor of CAD (OR=2.315), surpassing other risk factors like cholesterol and fibrinogen.

Conclusions:

  • Aortic valve calcification (AVC) is significantly associated with a higher prevalence and greater severity of coronary atherosclerotic disease (CAD).
Abstract

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