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Related Concept Videos

DNA Packaging00:58

DNA Packaging

Overview
DNA Packaging00:58

DNA Packaging

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The Nucleosome Core Particle01:12

The Nucleosome Core Particle

Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

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The paradox
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Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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Nucleoid01:24

Nucleoid

The nucleoid represents a structurally and functionally distinct region within prokaryotic cells, where the cell's DNA and associated proteins are housed. Unlike eukaryotic cells, prokaryotes lack a membrane-bound nucleus, and the nucleoid facilitates the organization and accessibility of the genetic material within this constraint. The DNA in most bacteria and archaea exists as a single, circular, double-stranded molecule that is highly compacted through supercoiling and interactions with...

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Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
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Published on: November 11, 2025

DNA Core@Inorganic Shell.

Dae-Hwan Park1, Jung-Eun Kim, Jae-Min Oh

  • 1Center for Intelligent NanoBio Materials (CINBM), Ewha Womans University, Seoul 120-750, Korea.

Journal of the American Chemical Society
|September 18, 2010
PubMed
Summary

Researchers developed a novel DNA Core@Metal Hydroxide Shell nanohybrid for enhanced gene delivery and diagnostics. This nanohybrid protects DNA information, enabling advanced biomedical applications.

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • DNA molecules are crucial for biological information but require protection for advanced applications.
  • Current methods for DNA stabilization and delivery face limitations in complex biological environments.

Purpose of the Study:

  • To create a stable nanohybrid system for encapsulating and releasing DNA molecules.
  • To explore the potential of this nanohybrid for gene delivery and biomedical diagnostics.

Main Methods:

  • Preparation of a DNA Core@Inorganic Shell nanohybrid using metal hydroxide (MH) nanosheets.
  • Utilizing the pH-dependent solubility of the MH nanoshell for controlled DNA release.
  • Characterization of the nanohybrid's structure, stability, and DNA encapsulation/release properties.

Main Results:

  • A stable nanohybrid with a ∼100 nm DNA core and a ∼10 nm MH nanoshell was successfully synthesized.
  • The nanohybrid demonstrated effective encapsulation and pH-controlled release of DNA molecules.
  • The system showed potential for preserving the integrity of sequence-manipulated and probe-functionalized DNA.

Conclusions:

  • The DNA Core@MH Shell nanohybrid offers a promising platform for advanced gene delivery systems.
  • This nanohybrid can be utilized in biomedical diagnostics, tracing, collection, and sensing of DNA-based information.
  • The integration of nanotechnology and bioinspired design opens new avenues for DNA-based information technologies.