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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Malignant eccrine spiradenoma: a meta-analysis of reported cases
Michael T Andreoli1, Kamal M F Itani
1Boston University, Boston, MA, USA.
American Journal of Surgery
|September 21, 2010
Summary
Aggressive surgical management for malignant eccrine spiradenoma improves outcomes. Local resection offers 100% disease-free survival without metastasis, while lymph node dissection is beneficial for nodal involvement.
Area of Science:
- Oncology
- Dermatopathology
- Surgical Oncology
Background:
- Malignant eccrine spiradenoma is an aggressive sweat gland tumor.
- Its behavior is poorly understood, and no standard treatment exists.
Purpose of the Study:
- To analyze survival outcomes for malignant eccrine spiradenoma.
- To evaluate the effectiveness of different surgical approaches.
Main Methods:
- Individual patient data meta-analysis of 72 reported cases.
- Kaplan–Meier survival curves were utilized.
Main Results:
- Local resection yielded 100% disease-free survival in patients without distant metastasis.
- Surgical resection with lymph node dissection resulted in disease-free survival for 6 of 7 patients with lymph node metastasis.
- No significant survival difference was observed for distant metastatic disease between local resection and adjuvant chemoradiotherapy.
Conclusions:
- Increased surgeon awareness of malignant eccrine spiradenoma is recommended.
- An aggressive surgical approach is supported for non-metastatic disease.
- Sentinel lymph node biopsy followed by dissection may be considered for clinically uninvolved lymph nodes.
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