Related Experiment Video
Updated: Jun 8, 2026
06:20
Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Resolution of lymphoma-associated open-angle glaucoma by rituximab.
Won I Kim1, Jeanette G Larar, Bruce D Cheson
1Brooke Army Medical Center, Fort Sam Houston, TX 78234-6200, USA. won.kim1@us.army.mil
Journal of Glaucoma
|September 21, 2010
Summary
A patient with open-angle glaucoma secondary to conjunctival lymphoid infiltrates experienced resolution of glaucoma after systemic rituximab treatment for lymphoma. This case highlights a unique cause of glaucoma and its successful management.
Area of Science:
- Ophthalmology
- Oncology
Background:
- Open-angle glaucoma can have varied etiologies, sometimes linked to systemic conditions.
- Conjunctival lymphoid infiltrates, often associated with lymphomas, can present unique challenges in ocular health.
Observation:
- A 67-year-old woman with non-Hodgkin lymphoma presented with uncontrolled open-angle glaucoma and bilateral perilimbal conjunctival lymphoid infiltrates.
- The patient had no intraocular involvement of the lymphoid disease.
Findings:
- Treatment of systemic lymphoma with rituximab led to the resolution of conjunctival lymphoid infiltrates and normalization of intraocular pressure.
- The patient remained glaucoma-free off medication for six years post-treatment, with no recurrence of conjunctival lesions or optic nerve damage.
Implications:
- Conjunctival lymphoid tumors can cause secondary open-angle glaucoma through obstruction of aqueous outflow.
- Systemic treatment of lymphoid lesions, such as with rituximab, can effectively resolve this unique form of glaucoma.
- This case underscores the importance of considering systemic conditions in the etiology of unexplained glaucoma.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...