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Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice

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Catherine M Herba¹, Sabine J Roza, Paul Govaert

¹Ste-Justine's Hospital Research Center, the University of Montreal.

Journal of the American Academy of Child and Adolescent Psychiatry

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Summary

Infant brain structure, specifically the gangliothalamic ovoid, may predict later internalizing problems. Smaller brain size in infancy is linked to increased anxiety and affective issues in early childhood.

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

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Published on: August 25, 2014

Area of Science:

Neuroscience
Developmental Psychology
Pediatrics

Background:

Previous studies show smaller subcortical volumes in adults/adolescents with depression and anxiety.
No prior research has examined these brain structures in infants before disorder onset.

Purpose of the Study:

To investigate if the size of the gangliothalamic ovoid (basal ganglia and thalamus) in infancy is associated with internalizing problems in early childhood.
To identify potential early biological markers for internalizing disorders.

Main Methods:

Cranial ultrasounds measured gangliothalamic ovoid diameter and ventricular volume at 6 weeks postnatal.
Child Behavior Checklist (CBCL) internalizing/externalizing problems were reported by parents at 18 and 36 months.
Analysis included 651 children, controlling for head circumference.

Main Results:

A smaller gangliothalamic ovoid diameter in infancy correlated with higher internalizing problem scores at 18 and 36 months.
This association remained significant after adjusting for head circumference.
Ventricular volume did not show a consistent association with internalizing scores.

Conclusions:

Infant gangliothalamic ovoid size is a potential predictor of childhood internalizing problems.
Findings suggest a biological vulnerability present in infancy, preceding disorder development.
Results align with prior research on smaller subcortical volumes in mood and anxiety disorders.