[Effect of biliary high pressure on hemodynamics and autonomic nervous activity]

An acutely experimental study on biliary compression and decompression as well as right splanchnic major nerve blocking was completed in Japanese big ear white rabbits. Using a self-made catheter with a blind cyst at bile duct, the extrahepatic biliary system could be cannulated and an experimental biliary high pressure of 150 mmHg could be achieved as long as 2 hours by water infusion via the blind cyst of the catheter. The right splanchnic major nerve was dissected simultaneously for investigating the impulse frequency of the nerve and the artery blood pressure during the study. A significant decrease in blood pressure (P less than 0.01) and an elevation of nervous impulse frequency (P less than 0.01) were found in "simple type" acute biliary high pressure without infection. Biliary decompression would immediately reverse the above abnormalities (P less than 0.01). The decline of blood pressure would be dramatically weaken or less significant if a right splanchnic nerve blocking was processed prior to biliary compression.