Related Experiment Video

Updated: Jun 8, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Adverse drug events in hospitalized patients with chronic kidney disease

Y Hassan1, R J Al-Ramahi, N A Aziz

  • 1School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia. yahaya@usm.my

International Journal of Clinical Pharmacology and Therapeutics
|September 24, 2010
PubMed

Insights

Adverse drug events (ADEs) are frequent in hospitalized patients with chronic kidney disease (CKD). A significant portion of these drug events were preventable, highlighting the need for pharmacist interventions to improve patient safety.

Area of Science:

  • Nephrology
  • Clinical Pharmacy
  • Pharmacovigilance

Background:

  • Adverse drug events (ADEs) are a significant cause of hospitalizations and complications.
  • Patients with chronic kidney disease (CKD) are particularly vulnerable to ADEs due to altered drug metabolism and excretion.

Purpose of the Study:

  • To determine the incidence, characteristics, severity, and preventability of pre-admission and in-hospital ADEs in CKD patients.
  • To identify medication classes most frequently associated with ADEs in this population.

Main Methods:

  • Retrospective review of medical records and charts of 300 adult CKD patients at a nephrology unit.
  • Daily assessment by a clinical pharmacist for evidence of drug-related errors or complications.
  • Detailed investigation of suspected ADEs to ascertain causality, severity, and preventability.

Main Results:

  • 159 ADEs were reported in 122 (40.7%) patients.
  • 48 (30.2%) of ADEs were deemed preventable.
  • Diuretics, antibacterials, antidiabetics, antithrombotics, mineral supplements, and antihypertensives were the most implicated drug classes.

Conclusions:

  • ADEs are highly prevalent in hospitalized CKD patients.
  • A substantial number of ADEs in this cohort are preventable.
  • Clinical pharmacist involvement shows potential for reducing ADEs and enhancing patient safety.
Abstract

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant01:25

Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant

In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...