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Published on: October 1, 2019
[Cardiopulmonary exercise testing in patients with pectus excavatum].
1Service de pneumologie et immunoallergologie, centre de compétence maladies pulmonaires rares, clinique des maladies respiratoires, hôpital Albert-Calmette, CHRU de Lille, boulevard du Professeur-Leclercq, 59037 Lille cedex, France.
Pectus excavatum (PE) significantly impairs exercise performance, affecting breathing, gas exchange, and cardiovascular function. These limitations are not predicted by PE severity or resting lung function tests.
Area of Science:
- Cardiology
- Pulmonology
- Exercise Physiology
Context:
- Pectus excavatum (PE) is a congenital chest wall deformity.
- The functional impact of PE on exercise capacity is not well understood.
- This study investigates exercise performance in individuals with PE.
Purpose:
- To determine the exercise performance and functional consequences of pectus excavatum.
- To identify patterns of physiological limitation during exercise in PE patients.
Summary:
- Thirty-two patients with PE underwent cardiopulmonary exercise testing (CPET), CT scans, pulmonary function tests, and echocardiography.
- Maximal oxygen uptake (VO(2-max)) was reduced to 78.6% predicted, with only 4 patients having normal CPET results.
- Limitations included impaired tidal volume expansion, abnormal gas exchange (potentially with patent foramen ovale), and cardiovascular impairment, with the latter group showing the most severe exercise limitation.
Impact:
- Pectus excavatum is associated with significant exercise limitations affecting ventilatory, gas exchange, and cardiovascular systems.
- Cardiopulmonary exercise testing reveals abnormalities not predicted by PE severity or resting pulmonary function.
- Findings highlight the importance of CPET in managing patients with pectus excavatum and understanding their functional capacity.
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