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Updated: Jun 8, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
07:48

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Advanced bladder cancer: new agents and new approaches. A review

Andrea Volpe1, Marco Racioppi, Daniele D'Agostino

  • 1Department of Urology, Catholic University of the Sacred Heart, Rome, Italy. dr.avolpe@gmail.com

Urologic Oncology
|September 25, 2010
PubMed
Abstract

Insights

This review evaluates new drugs for metastatic urothelial cancer. Future treatments will combine optimized chemotherapy with targeted therapies based on tumor molecular profiles.

Area of Science:

  • Oncology
  • Urothelial Carcinomas
  • Medical Treatments

Background:

  • Metastatic urothelial cancer treatment remains challenging.
  • Radical cystectomy with pelvic lymph node dissection is standard for localized disease.
  • Systemic therapies are crucial for eradicating micrometastases and improving survival.

Purpose of the Study:

  • To review current findings on metastatic urothelial cancer treatment.
  • To evaluate the potential of novel therapeutic agents.
  • To inform future diagnostic and therapeutic strategies.

Main Methods:

  • Literature search of MEDLINE and PubMed databases up to 2009.
  • Used Medical Subject Headings (MeSH) and free text searches for chemotherapy drugs and bladder cancer keywords.
  • Included studies with at least 30 patients.

Main Results:

  • Radical cystectomy with pelvic lymph node dissection is the gold standard for localized muscle-invasive bladder cancer.
  • Perioperative chemotherapy (neoadjuvant or adjuvant) can eradicate subclinical disease and improve survival.
  • More extensive lymph node dissection may offer prognostic and therapeutic benefits.

Conclusions:

  • Integrating knowledge is key for developing optimal therapeutic and diagnostic strategies.
  • Future advancements depend on optimizing cytotoxic agents and targeting molecular aberrations.
  • Personalized medicine approaches considering individual tumor biology are essential for advanced bladder cancer treatment.

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