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[Expression and significance of STAT3 and VEGF with MVD in the nasal polyps]
Qingsong Cao1, Tao Zhang, Lixin Jiang
1Department of Otorhinolaryngology, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China. yyzm333@163.com
Objective:
To investigate microvessel density (MVD) and expressions of phosphor-STAT3 and vascular endothelial growth factor (VEGF) in nasal polyps, to explore their pathogenetic correlations.
Method:
All selected cases were measured up the standard of enrollment. Thirty samples of nasal polyps were obtained from patients undergoing nasal polypectomy, and 10 samples of inferior turbinate tissues were from patients undergoing nasal septal construction. p-STAT3,VEGF and MVD in nasal polyp tissues from 30 nasal polyposis patients and 10 samples of inferior turbinate tissues were detected with immunohistochemistry (sp) method.
Result:
In nasal polyp tissues, The positive rates of p-STAT3 and VEGF expression were 60% and 70% respectively, all were significantly higher in nasal polyps than in control inferior turbinates (P < 0.01). MVD was significantly higher in nasal polyps than in control inferior turbinates (22.78 +/- 7.89 vs 7.12 +/- 2.84, P < 0.01). p-STAT3 expression was positively correlated with VEGF expression and MVD.
Conclusion:
p-STAT3, VEGF and MVD were overexpressed in the tissues of nasal polyps, and p-STAT3 expression was positively correlated with VEGF expression and MVD; p-STAT3 was positively correlated with the neovascularization of nasal polyps, The inhibition of STAT3 pathway may inhibit the neovascularization, and then inhibit the formation and recurrence of the nasal polyps.
Insights
Phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and vascular endothelial growth factor (VEGF) are elevated in nasal polyps, correlating with increased microvessel density (MVD). Targeting the STAT3 pathway may reduce polyp neovascularization and recurrence.
Area of Science:
- Otorhinolaryngology
- Molecular Biology
- Pathology
Context:
- Nasal polyps are associated with chronic inflammation and tissue remodeling.
- Neovascularization plays a critical role in the pathogenesis of nasal polyps.
Purpose:
- To investigate the expression levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), vascular endothelial growth factor (VEGF), and microvessel density (MVD) in nasal polyps.
- To explore the correlations between p-STAT3, VEGF, and MVD in the development of nasal polyps.
Summary:
- Immunohistochemistry revealed significantly higher positive rates of p-STAT3 (60%) and VEGF (70%) in nasal polyp tissues compared to inferior turbinates.
- Microvessel density (MVD) was markedly elevated in nasal polyps (22.78 ± 7.89) versus controls (7.12 ± 2.84).
- p-STAT3 expression demonstrated a positive correlation with VEGF expression and MVD in nasal polyps.
Impact:
- These findings suggest that p-STAT3, VEGF, and MVD are overexpressed in nasal polyps.
- The positive correlation between p-STAT3 and neovascularization indicates that inhibiting the STAT3 pathway could be a therapeutic strategy to prevent nasal polyp formation and recurrence.
