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Updated: Jun 8, 2026

Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
Epigenetic regulation of aging
Sandra Rodríguez-Rodero1, Juan Luis Fernández-Morera, Agustin F Fernandez
1Department of Endocrinology and Nutrition Service, Hospital Universitario Central de Asturias, Oviedo, 33006, Spain.
Aging involves complex genetic and epigenetic interactions, influencing health and disease across generations. Understanding epigenetics is key to addressing age-related changes and inherited health risks.
Area of Science:
- Biology
- Genetics
- Epigenetics
Background:
- Aging is a complex biological problem with significant public health implications.
- Age-related diseases and physical decline are major concerns for longevity.
- Epigenetics plays a crucial role in understanding aging and its associated diseases.
Purpose of the Study:
- To explore the intricate role of epigenetics in the aging process.
- To elucidate how epigenetic modifications influence age-related phenotypic differences and diseases.
- To highlight the impact of inherited epigenetic factors on health outcomes.
Main Methods:
- Review of current literature on aging and epigenetics.
- Analysis of genetic and epigenetic interactions at various biological levels.
- Examination of DNA plasticity and its epigenetic mediation.
Main Results:
- Epigenetics is central to phenotypic variation during aging.
- Epigenetic mechanisms link genetic background, environment, aging, and disease.
- Epigenetic changes can influence cell function and be inherited.
Conclusions:
- Epigenetics is fundamental to understanding the complexity of aging.
- Epigenetic inheritance from ancestors impacts an individual's health.
- Further research into epigenetics can inform strategies for healthy aging.
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