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Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways
Christa Buechler1, Josef Wanninger, Markus Neumeier
1Department of Internal Medicine I, University Hospital of Regensburg, Regensburg, Germany. christa.buechler@klinik.uni-regensburg.de
Adiponectin, reduced in obesity, improves insulin sensitivity. This review covers adiponectin receptors (AdipoR1/AdipoR2) and their associated proteins, including APPL1, crucial for adiponectin bioactivity.
Area of Science:
- Endocrinology
- Molecular Biology
- Cell Biology
Background:
- Adiponectin levels decrease in obesity-related diseases, impacting insulin sensitivity.
- Adiponectin exerts pleiotropic effects on apoptosis, proliferation, migration, and inflammation.
- Adiponectin exerts its functions by binding to ubiquitously expressed receptors, AdipoR1 and AdipoR2.
Purpose of the Study:
- To review recent findings on adiponectin receptor associated proteins.
- To summarize studies utilizing heterologous expression of adiponectin receptors in yeast.
- To elucidate the function of AdipoR1 and AdipoR2 binding proteins.
Main Methods:
- Review of recent scientific literature.
- Analysis of studies involving heterologous expression of adiponectin receptors in yeast.
- Identification and characterization of adiponectin receptor associated proteins.
Main Results:
- Adiponectin receptor associated proteins, such as APPL1, bind to AdipoR1 and AdipoR2.
- Complex formation of AdipoR1 with protein kinase C1, endoplasmic reticulum protein 46, and protein kinase CK2β subunit has been identified.
- Clathrin-dependent endocytosis of AdipoR1 and adiponectin influences adiponectin bioactivity.
Conclusions:
- Adiponectin receptor associated proteins play a significant role in mediating adiponectin signaling.
- Understanding these interactions is crucial for deciphering adiponectin's role in metabolic regulation.
- Heterologous expression systems provide valuable tools for studying adiponectin receptor function and interactions.
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