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Targets for neural repair therapies after stroke

S Thomas Carmichael1

  • 1Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. scarmichael@mednet.ucla.edu

Stroke
|September 30, 2010
PubMed

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...