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Updated: Jun 8, 2026

A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
Published on: May 10, 2022
CYP2D6 polymorphism in patients with eating disorders
E M Peñas-Lledó1, P Dorado, Z Agüera
1CICAB Clinical Research Center, Extremadura University Hospital Medical School, Fundesalud and CIBERSAM, Badajoz, Spain.
Genetic variations in CYP2D6, an enzyme affecting drug metabolism, may increase eating disorder risk. Ultrarapid metabolizers with more active CYP2D6 genes were more common in patients with eating disorders.
Area of Science:
- Pharmacogenetics
- Psychiatry
- Genetics
Background:
- Cytochrome P450 2D6 (CYP2D6) genetic polymorphism influences drug metabolism and endogenous processes.
- CYP2D6 activity variability is linked to personality, neurocognition, and psychopathology.
Purpose of the Study:
- To investigate the association between CYP2D6 genetic polymorphism and the risk of developing eating disorders (ED).
Main Methods:
- A case-control study comparing CYP2D6 active allele distribution in 267 patients with ED and 285 controls.
- Statistical analysis of allele frequencies between patient and control groups.
Main Results:
- Significant differences in CYP2D6 active allele distribution were observed between ED patients and controls.
- Individuals with more than two (ultrarapid metabolizers) or two active CYP2D6 genes were more prevalent in the ED group.
- Conversely, individuals with one or zero active CYP2D6 genes were more frequent in the control group (P<0.05).
Conclusions:
- Findings suggest a potential association between CYP2D6 genetic variations and an increased risk of eating disorders.
- The observed CYP2D6 allele distribution in ED patients indicates a tendency towards increased enzyme activity.
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