Related Experiment Video
Updated: Jun 8, 2026

NMR 15N Relaxation Experiments for the Investigation of Picosecond to Nanoseconds Structural Dynamics of Proteins
Published on: November 1, 2024
(119/117/115)Sn low-abundance single-transition correlation spectroscopy (LASSY): sensitivity-enhanced homonuclear
Christy George1, Narayanan Chandrakumar
1Department of Chemistry, Indian Institute of Technology-Madras, Chennai 600036, Tamil Nadu, India.
Abstract:
We report the implementation of our novel rare-spin homonuclear correlation experiment, namely, Low-Abundance Single-transition correlation SpectroscopY (LASSY), for (119/117/115)Sn NMR at natural abundance. Our pulse sequence results in diagonal suppressed COSY-style display and outperforms the optimal homonuclear correlation experiment for rare spins, which involves double quantum evolution (INADEQUATE CR). The new experiment maximizes efficiency both in respect of pulse transformations as well as relaxation effects, and gives rise to a simplified two-dimensional (2D) spectrum with considerably reduced crowding, exhibiting only one transition in each cross peak, instead of four. Performance optimization of LASSY is carried out in light of the relatively 'large' line widths typical of Sn NMR in solution state. The superior performance of the sequence is demonstrated on dimeric tetraorganodistannoxane samples.
More Related Videos
Related Concept Videos
2D NMR: Overview of Homonuclear Correlation Techniques
COSY90 is the standard two-dimensional (2D) COSY experiment that...
2D NMR: Overview of Heteronuclear Correlation Techniques
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
2D NMR: Homonuclear Correlation Spectroscopy (COSY)
¹H NMR: Interpreting Distorted and Overlapping Signals
As Δν decreases and the signals move closer, the doublets appear increasingly distorted. The intensities of the inner lines increase at the cost of those of the outer lines as the signals are slanted or...
NMR Spectroscopy: Spin–Spin Coupling

