Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What Makes a Useful "Predictor" of Risk for Suicide Attempt?

JAMA psychiatry·2022
Same author

Children's neural reactivity to maternal praise and criticism: Associations with early depressive symptoms and maternal depression.

Development and psychopathology·2022
Same author

Whole-Brain Resting-State Functional Connectivity Patterns Associated With Pediatric Anxiety and Involuntary Attention Capture.

Biological psychiatry global open science·2022
Same author

Correction To: Childhood Behavioral Inhibition and Overcontrol: Relationships with Cognitive Functioning, Error Monitoring, Anxiety and Obsessive-compulsive Symptoms.

Research on child and adolescent psychopathology·2022
Same author

Developmental trajectories of cortical thickness by functional brain network: The roles of pubertal timing and socioeconomic status.

Developmental cognitive neuroscience·2022
Same author

Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis.

Translational psychiatry·2022
Same journal

Decoding neuronal criticality firing patterns for large brain based EEG models.

NeuroImage·2026
Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
See all related articles

Related Experiment Video

Updated: Jun 8, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Error processing network dynamics in schizophrenia.

Karla E Becerril1, Grega Repovs, Deanna M Barch

  • 1Neuroscience Program, Department of Psychology, Washington University in St. Louis, St. Louis, MO 63130, USA. kebecerr@wustl.edu

Neuroimage
|October 2, 2010
PubMed
Summary
This summary is machine-generated.

Individuals with schizophrenia show impaired error monitoring and behavioral adjustment due to altered brain network function, particularly in the dorsal anterior cingulate cortex (dACC). This impacts cognitive control and highlights the need for network-based research.

More Related Videos

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Related Experiment Videos

Last Updated: Jun 8, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Cognitive dysfunction in schizophrenia involves impaired self-monitoring and behavioral adaptation.
  • Error detection is crucial for flexible behavior adjustment, with the dorsal anterior cingulate cortex (dACC) heavily implicated.
  • Error processing involves a distributed network beyond the dACC, including anterior insula, parietal cortex, and cerebellum.

Purpose of the Study:

  • To investigate error-related brain activity in schizophrenia within a distributed network.
  • To determine if abnormalities extend beyond the dACC in schizophrenia.
  • To examine the relationship between brain activity, behavioral adjustments, and network connectivity.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to study 37 individuals with schizophrenia and 32 healthy controls.
  • Error-related responses were examined in predefined regions involved in error processing.
  • Connectivity analysis assessed network integration between regions.

Main Results:

  • Individuals with schizophrenia exhibited blunted error-related responses in the dACC and other network regions compared to controls.
  • Abnormalities in error processing extended beyond the dACC to most regions in the network.
  • dACC activity was most predictive of behavioral adjustments in both groups, but network integration, particularly with cerebellar regions, was reduced in schizophrenia.

Conclusions:

  • Schizophrenia is associated with widespread abnormalities in the neural network supporting error processing and behavioral adjustment.
  • Blunted dACC responses and reduced network connectivity contribute to impaired cognitive control in schizophrenia.
  • Understanding error processing within a distributed network framework is crucial for schizophrenia research.