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Updated: Jun 8, 2026
07:11
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Hybrid cyclic peptide-thiourea cryptands for anion recognition
Philip G Young1, Jack K Clegg, Mohan Bhadbhade
1School of Chemistry, The University of Sydney, 2006 NSW, Australia.
Chemical Communications (Cambridge, England)
|October 2, 2010
Summary
Two novel cyclic peptide cryptands with thiourea frameworks were synthesized. These neutral receptors demonstrate high affinity binding for acetate ions, with one showing notable selectivity.
Area of Science:
- Supramolecular Chemistry
- Organic Synthesis
Background:
- Anion recognition is crucial in biological and chemical processes.
- Developing synthetic receptors for specific anions remains a challenge.
Purpose of the Study:
- To synthesize novel cyclic peptide derived cryptands.
- To investigate their potential as neutral anion receptors.
Main Methods:
- Synthesis of two cyclic peptide derived cryptands.
- Incorporation of thiourea moieties into the cryptand framework.
- Anion binding studies, focusing on acetate ions.
Main Results:
- Successful synthesis of two cyclic peptide derived cryptands.
- Demonstrated high affinity binding of acetate ions by both receptors.
- One cryptand exhibited good selectivity for acetate ions.
Conclusions:
- Cyclic peptide derived cryptands with thiourea groups are effective neutral anion receptors.
- These compounds show promise for selective acetate recognition.
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