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Updated: Jun 8, 2026

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

Published on: April 7, 2023

Encoded anisotropic particles for multiplexed bioanalysis.

Kristin B Cederquist¹, Stacey L Dean, Christine D Keating

¹Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|October 5, 2010

Summary

This summary is machine-generated.

Anisotropic encoded nanoparticles offer advanced bioanalysis through diverse synthesis methods. These particles enable high-multiplexing biosensing for various biological targets, showing promise in commercial applications.

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Multiplexed Barcoding Image Analysis for Immunoprofiling and Spatial Mapping Characterization in the Single-Cell Analysis of Paraffin Tissue Samples

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Area of Science:

Nanotechnology and Materials Science
Biotechnology and Bioanalysis
Analytical Chemistry

Background:

Encoded anisotropic nanoparticles are a novel class of materials for bioanalysis.
Particle encoding can be achieved through shape, composition, topography, or optical properties.
These particles offer unique advantages for multiplexed detection strategies.

Purpose of the Study:

To review synthetic methods for creating anisotropic encoded particles.
To evaluate these particles as platforms for multiplexed biosensing.
To highlight their potential for high-throughput bioassays.

Main Methods:

Exploration of various synthetic routes for anisotropic particle formation.
Assessment of encoding strategies (shape, composition, topography, optical properties).
Review of suspension array technologies utilizing these particles.

Main Results:

Anisotropic particles have been successfully synthesized and encoded.
Demonstrated detection of diverse analytes including proteins, nucleic acids, cells, and small molecules.
Potential for achieving thousands of unique codes, enabling ultra-high multiplexing.

Conclusions:

Anisotropic encoded particles are a versatile platform for advanced bioanalysis.
Multiplexed bioassays using these particles are feasible and increasingly adopted.
Further development promises significant advancements in diagnostic and research tools.