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Inhibition of posterior capsule opacification by 5-fluorouracil in rabbits
J M Ruíz1, M Medrano, J L Alió
1División de Oftalmología, Facultad de Medicina, Universidad de Alicante, España.
Ophthalmic Research
|January 1, 1990
Abstract:
An extracapsular cataract extraction was performed on both eyes of 24 rabbits. Irrigation for 10 min of the capsular bag of the left (test) eye with 8-12 cm3 of 1 litre of BSS-plus to which had been added 50 mg of 5-fluorouracil significantly inhibited proliferation of the anterior capsular epithelium as compared with the right (control) eyes identically treated except for the omission of 5-fluorouracil (p less than 0.001). Corneal endothelial counts did not differ significantly. A reduction in opacification of the posterior capsule is expected from 5-fluorouracil treatment.