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Updated: Mar 10, 2026

Glucose-Stimulated Insulin Secretion via Perfusion through the Mice Vasculature with an Intact Pancreas
Published on: July 25, 2025
Increased glucose content in the aqueous humour caused by the use of xylazine
1Department of Clinical Studies, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Abstract:
Xylazine has a strong hyperglycaemic effect due to its blocking of the pancreatic insulin release via stimulation of parasympathetic (alpha 2-adrenergic) receptors. Therefore xylazine also increases the content of glucose in the aqueous humour considerably. This increase might be regarded as the inducing factor of the diabetogenic cataractous changes seen in animals with a low tolerance to high glucose levels in the aqueous humour. Xylazine must still be regarded as one of the better combinations with ketamine, because of its reproducible and stable anaesthetic effect in this combination in cats. However, the use of xylazine should be carefully considered, especially in eye surgery, until further controlled information is available.
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