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Clinical inquiries. Which drugs are best when aggressive Alzheimer's patients need medication?
Brice Labruzzo Mohundro1, Karla Pope, Vincent Shaw
1Baton Rouge General Family Medicine Residency Program, ULM College of Pharmacy, Baton Rouge, LA, USA.
Abstract:
Atypical antipsychotics are effective; so are selective serotonin reuptake inhibitors (SSRIs), and they may be safer. Atypical antipsychotics are an effective short-term (6-12 weeks) treatment for aggressive behavior in patients with Alzheimer's disease because they consistently decrease aggression scores (strength of recommendation [SOR]: A, multiple randomized controlled trials [RCTs]). However, evidence of drug-related deaths in patients taking these drugs mandates weighing the benefits against the risks. SSRIs may be a safer, effective alternative (SOR: B, limited studies).
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