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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
New reactions of anticancer-platinum complexes and their intriguing behaviour under various experimental conditions
José Alemán1, Virginia del Solar, Leticia Cubo
1Departamento de Química Orgánica (M-I), Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain. jose.aleman@uam.es
Abstract:
The anticancer platinum complexes here described react with organic substrates (such as acids, alkenes, alkynes) and catalyze transformations that can occur in biomolecules which contain unsaturated functions. We have analyzed the role of the platinum complexes in the observed reactions and studied the progress of the detected transformations upon variation of the reaction conditions.

