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Related Experiment Video

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Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1⁺ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

Published on: March 27, 2019

6q24 transient neonatal diabetes.

I Karen Temple¹, Julian P H Shield

¹Academic Unit of Genetic Medicine, Princess Anne Hospital, Coxford Road, Southampton, SO16 5YA, UK. ikt@soton.ac.uk

Reviews in Endocrine & Metabolic Disorders

|October 6, 2010

Summary

Transient Neonatal Diabetes (TND) is a common cause of early-onset diabetes, often resolving within months but increasing type 2 diabetes risk later. Early diagnosis is crucial for treatment and identifying complex imprinting disorders.

Area of Science:

Endocrinology
Genetics
Neonatal Medicine

Background:

Transient Neonatal Diabetes (TND) is the most frequent cause of diabetes in the first week of life.
While most infants recover by three months, they face an increased risk of developing type 2 diabetes later.
TND is linked to low birth weight with subsequent catch-up growth by one year.

Purpose of the Study:

To summarize the key features, genetic underpinnings, and clinical implications of Transient Neonatal Diabetes.
To highlight the importance of early diagnosis in managing TND and differentiating it from other neonatal diabetic conditions.
To underscore the association of TND with broader imprinting disorders and developmental issues.

Main Methods:

Review of existing literature on Transient Neonatal Diabetes.

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Analysis of genetic and epigenetic factors, particularly aberrations at chromosome 6q24.

Clinical case study considerations for diagnosis and management.

Main Results:

TND is typically caused by genetic or epigenetic abnormalities at the 6q24 imprinted locus.
The condition can be sporadic or inherited, with a predisposition to later type 2 diabetes.
In some cases, TND may indicate a more complex imprinting disorder linked to ZFP57 gene mutations and developmental problems.

Conclusions:

Early diagnosis of TND is essential for appropriate medical management and distinguishing it from other forms of early-onset diabetes.
Understanding the genetic basis of TND aids in predicting long-term health risks, including type 2 diabetes.
TND can serve as an early indicator of underlying imprinting disorders, necessitating comprehensive patient evaluation.