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Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Clinical Trials: Overview01:11

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Updated: Jan 14, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
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EndoCompass project: research roadmap for growth disorders.

Evelien F Gevers1,2, Anita C Hokken-Koelega3, Maithe Tauber4

  • 1Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

European Journal of Endocrinology
|October 17, 2025
PubMed
Summary
This summary is machine-generated.

Endocrinology research needs greater EU funding. The EndoCompass project identified key priorities in growth disorders, aiming to improve hormone health and reduce disease burden through strategic investment.

Keywords:
Noonan syndromePrader-Willi syndromeSilver-Russell syndromegrowth hormoneimprinting disordersshort staturetall stature

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Area of Science:

  • Endocrinology and hormone health research.
  • Focus on pediatric endocrine disorders and growth regulation.

Background:

  • Endocrine science is underrepresented in EU research funding despite significant societal impact.
  • A gap exists between the impact of endocrine disorders and their research prioritization.
  • National funding often overlooks endocrinology.

Purpose of the Study:

  • To identify and promote strategic research priorities in endocrine science.
  • To address critical hormone-related health challenges.
  • To align research funding with areas of high potential impact.

Main Methods:

  • Analysis of the EU CORDIS database (Horizon 2020).
  • Expert consultations on growth disorders.
  • Stakeholder engagement with patient advocacy groups.

Main Results:

  • Priorities include genetic diagnosis, growth plate therapies, and molecular mechanisms of specific syndromes (Silver-Russell, imprinting disorders, Prader-Willi, Noonan syndrome).
  • Emphasis on disease registries for outcome studies.
  • Development of precision therapeutics targeting growth regulation.

Conclusions:

  • An evidence-based roadmap for strategic research investment in growth disorders.
  • Identifies key areas for research in pathophysiology, prevention, and treatment.
  • Aims to reduce the burden of endocrine disorders on individuals and society.