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Updated: Jun 8, 2026
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Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
Published on: June 25, 2018
A concise and convergent synthesis of PA-824
Maurice A Marsini1, Paul J Reider, Erik J Sorensen
1Department of Chemistry, Frick Chemical Laboratory, Princeton University, Princeton, New Jersey 08544, United States.
The Journal of Organic Chemistry
|October 9, 2010
Abstract:
An efficient four-step synthesis of PA-824, a promising antituberculosis drug candidate, has been developed. This concise approach offers significant improvements over the synthetic route currently used for large-scale production.
