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Updated: Jun 8, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Published on: May 22, 2018
Ultrafiltrate of blood plasma modulates amyloid-β aggregation
Aleksandra Nowicka1, Andrzej A Szczepankiewicz, Andrzej Jaklewicz
1Warsaw University of Life Sciences - SGGW, Warsaw, Poland.
Abstract:
Several neurodegenerative diseases, including Alzheimer's disease (AD), have etiology connected to abnormal protein self association. Copper-induced striking differences in amyloid-β40 aggregation, distinct from spontaneous self association, prompted us to study whether amyloid-β40 aggregation could be applied to differentiate between platelet poor plasma ultrafiltrates obtained from AD and control samples. We report, based on 20 AD and 18 age-matched controls, a significant difference in the concentration of short fibers induced by ultrafiltrated plasma from AD compared to control samples. The observed effect was independent of copper and other EDTA chelatable ions.
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