Secondary diabetic complications and biochemical parameters

Area of Science:

• Endocrinology and Metabolism
• Clinical Biochemistry

Background:

• Diabetes mellitus is a chronic metabolic disorder with potential for severe secondary complications.
• Understanding biomarker variations in diabetic patients with and without complications is crucial for risk stratification and management.

Purpose of the Study:

• To compare biochemical and physiological parameters between Libyan diabetic patients with and without secondary complications.
• To investigate the relationship between diabetes duration and the presence of secondary complications.

Main Methods:

• Comparative analysis of mean values for body mass index, hemoglobin A1, serum protein, lipids, enzymes, and cardiovascular markers.
• Statistical comparison between two groups: diabetic patients with secondary complications and those without.
• Assessment of diabetes duration in both patient groups.

Main Results:

• Significantly higher mean levels of body mass index, hemoglobin A1, serum protein, triglycerides, lactate dehydrogenase, alkaline phosphatase, amylase, beta-glucuronidase, heart rate, blood pressure, and blood urea in patients with secondary complications.
• Conversely, patients without complications exhibited higher mean levels of fasting blood glucose, serum cholesterol, and beta-N-acetylglucosaminidase.
• The mean duration of diabetes was notably longer in patients with secondary complications (10.2 years) compared to those without (5.2 years).

Conclusions:

• Distinct biomarker profiles differentiate Libyan diabetic patients with and without secondary complications.
• Longer diabetes duration is strongly associated with the development of secondary complications.
• These findings highlight the importance of monitoring specific biomarkers and managing diabetes duration to prevent complications.