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Related Concept Videos

Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
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Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

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Consortium for Blood Group Genes (CBGG): 2009 report.

G A Denomme1, C M Westhoff, L M Castilho

  • 1Immunology Reference Laboratory, BloodCenter of Wisconsin, 638 N 18th Street, PO Box 2178, Milwaukee, WI 53201-2178, USA.

Immunohematology
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

The Consortium for Blood Group Genes facilitates global collaboration in blood group genetics, offering guidelines and education for DNA/RNA testing. It addresses challenges in allele nomenclature and laboratory data storage.

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Area of Science:

  • Genetics
  • Immunology
  • Bioinformatics

Background:

  • The Consortium for Blood Group Genes is a global organization focused on DNA and RNA testing for blood group, platelet, and neutrophil antigens.
  • It aims to foster interaction, establish guidelines, operate proficiency programs, and provide education for laboratories.
  • Current operations involve representatives from Brazil, Canada, and the United States, with voluntary membership.

Purpose of the Study:

  • To outline the structure and function of the Consortium for Blood Group Genes.
  • To highlight recent developments within the consortium, including changes in leadership and the addition of a human platelet antigen representative.
  • To identify future challenges and directions for the organization.

Main Methods:

  • The consortium operates through voluntary membership and active participation of representatives.
  • Discussions involve blood group genetics, nomenclature, and laboratory information systems.
  • Recent changes include updates to standing committee membership and the establishment of a new representative role.

Main Results:

  • The consortium has established a framework for international collaboration in blood group genetics.
  • A representative for the human platelet antigens group has been appointed.
  • The consortium has identified key challenges for future development.

Conclusions:

  • The Consortium for Blood Group Genes plays a vital role in advancing blood group genetics research and laboratory practices.
  • Future efforts will focus on standardizing nomenclature and improving laboratory information systems for genotype data.
  • Continued international collaboration is essential for addressing these challenges.