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Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group with both...
Radicals: Electronic Structure and Geometry01:07

Radicals: Electronic Structure and Geometry

This lesson delves into the geometry of a radical, which is influenced by the electronic structure of the molecule. The principle is similar to that of a lone pair, where the unpaired electron influences the geometry at the radical center.
Accordingly, the structure of a trivalent radical lies between the geometries of carbocations and carbanions. An sp2-hybridized carbocation is trigonal planar, while an sp3-hybridized carbanion is trigonal pyramidal. Here, the difference in geometry is...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3 variants are also...
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.

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Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution
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Published on: January 16, 2017

RHCE*ceAR encodes a partial c (RH4) antigen.

C Halter Hipsky1, C Lomas-Francis, A Fuchisawa

  • 1Laboratory of Immunochemistry, New York Blood Center, 310 East 67th Street, New York, NY 10065, USA.

Immunohematology
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

This study identified a novel partial c antigen in an African American man with sickle cell disease. DNA testing confirmed the presence of a rare RHCE variant, explaining the alloanti-c antibody formation.

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Published on: October 25, 2016

Area of Science:

  • Immunology
  • Genetics
  • Hematology

Background:

  • The Rh blood group system is characterized by numerous antigens, with partial D and e antigens being particularly complex.
  • Recent reports have highlighted the existence of several partial c antigens.
  • Understanding these variations is crucial for transfusion medicine.

Observation:

  • * A case involving an African American man with sickle cell disease is presented.
  • * The patient's red blood cells (RBCs) typed as C+c+, yet his plasma contained anti-c antibodies.
  • * Standard serological and molecular techniques were employed for analysis.

Findings:

  • * DNA analysis revealed the presence of RHCE*Ce alongside RHCE*ceAR, RHD*D, and RHD*Weak D type 4.2.2.
  • * Specific amino acid alterations in RhceAR were identified as the cause of the partial c antigen.
  • * This genetic configuration led to the patient producing alloanti-c despite a C+c+ typing.

Implications:

  • * The RhceAR variant carries a partial c antigen, contributing to alloimmunization.
  • * DNA testing is a valuable tool for identifying unusual antibodies in complex Rh cases.
  • * This finding enhances the understanding of Rh antigen diversity and its clinical significance.