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Updated: Jun 8, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
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Phage display technology for stem cell delivery and systemic therapy.

Fernanda I Staquicini1, Richard L Sidman, Wadih Arap

  • 1The University of Texas M. D. Anderson Cancer Center, Houston, USA.

Advanced Drug Delivery Reviews
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

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Phage display technology enables targeted therapies and molecular imaging by identifying specific molecular complexes. This approach enhances understanding of cellular and vascular proteomics, particularly in cancer research and treatment.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Pharmacology

Background:

  • Phage display technology has advanced significantly, enabling in vivo applications.
  • This technology allows for the identification of specific molecular targets on cells and blood vessels.

Purpose of the Study:

  • To review the implications of in vivo phage display for ligand-directed pharmacology.
  • To highlight its role in therapeutic and molecular imaging applications.
  • To discuss the use of phage-based agents delivered via stem and progenitor cells.

Main Methods:

  • In vivo phage display for identifying molecular targets.
  • Development of peptide and gene-based therapeutic and imaging agents.
  • Utilizing stem and progenitor cells for targeted delivery.

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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
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Related Experiment Videos

Last Updated: Jun 8, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
06:30

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
07:53

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

Main Results:

  • Identification of specific molecular complexes on vascular and parenchymal cells.
  • Demonstrated efficacy of phage-based agents in experimental models and patients.
  • Potential for enhanced understanding of proteomics in various tissues.

Conclusions:

  • In vivo phage display offers a powerful platform for targeted medicine and molecular imaging.
  • This technology contributes to a deeper understanding of molecular mechanisms, especially in carcinogenesis.
  • Phage display, particularly with stem cell delivery, is increasingly impacting modern medicine.