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Related Concept Videos

Capillary Electrophoresis: Applications01:30

Capillary Electrophoresis: Applications

Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
Electrophoresis: Overview01:20

Electrophoresis: Overview

Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...
Capillary Electrophoresis: Instrumentation01:20

Capillary Electrophoresis: Instrumentation

Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...

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Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay
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Published on: February 23, 2020

Dielectrophoretic platforms for bio-microfluidic systems.

Khashayar Khoshmanesh1, Saeid Nahavandi, Sara Baratchi

  • 1Centre for Intelligent Systems Research, Deakin University, Pignonds Road, Waurn Ponds, VIC 3217, Australia. kkho@deakin.edu.au

Biosensors & Bioelectronics
|October 12, 2010
PubMed
Summary
This summary is machine-generated.

Dielectrophoresis (DEP) in microfluidics offers label-free, sensitive bioparticle analysis. This review details DEP platforms for biomedical uses, classifying electrode designs and strategies for future lab-on-a-chip systems.

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Published on: November 23, 2015

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Biophysics

Background:

  • Dielectrophoresis (DEP) utilizes non-uniform electric fields to move polarizable particles.
  • Microfluidic systems integrate DEP for efficient manipulation of micro/nano bioparticles.
  • DEP enables label-free, sensitive, and selective detection of biological targets.

Purpose of the Study:

  • To provide a comprehensive review of dielectrophoretic (DEP) platforms in microfluidics for biomedical applications.
  • To classify current DEP systems based on microelectrode configurations and operating strategies.
  • To discuss future trends and potential applications of DEP in advanced biological analyses.

Main Methods:

  • Review of state-of-the-art dielectrophoretic (DEP) platforms.
  • Classification of DEP systems by microelectrode configurations.
  • Analysis of operating strategies for DEP force generation and application.

Main Results:

  • DEP integration in microfluidics facilitates inexpensive, fast, and highly sensitive bioparticle detection.
  • Various microelectrode designs and operating strategies are employed for DEP manipulation.
  • DEP systems show significant promise for diverse biomedical applications.

Conclusions:

  • DEP is a versatile tool for bioparticle transport, accumulation, separation, and characterization in microfluidics.
  • Future trends include single-cell analysis, stem cell research, and fully automated lab-on-a-chip devices.
  • DEP-based microfluidic platforms are crucial for advancing biomedical diagnostics and research.