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Updated: Jun 8, 2026

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

[Expression profiles of microRNA in colon adenocarcinoma]

Ming-Xin Zhang1, Hui Cai, Jian-Sheng Wang

  • 1Department of Oncology Surgery, the First Affiliated Hospital of Medical College, Xi'an 710061, China.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chinese Journal of Cellular and Molecular Immunology
|October 13, 2010
PubMed
Abstract

Insights

MicroRNA (miRNA) expression differs between colon adenocarcinoma and normal tissue. These distinct miRNAs may serve as biomarkers for colon cancer diagnosis and potential therapeutic targets.

Area of Science:

  • Molecular biology
  • Genomics
  • Cancer research

Context:

  • Colon adenocarcinoma is a significant global health concern.
  • Understanding the molecular mechanisms underlying colon cancer is crucial for developing effective treatments.
  • MicroRNAs (miRNAs) have emerged as key regulators in various cellular processes, including cancer development.

Purpose:

  • To investigate differential microRNA (miRNA) expression profiles in colon adenocarcinoma compared to adjacent non-tumorous tissue (NT).
  • To explore the potential role of miRNAs in the molecular mechanisms of colon adenocarcinoma.
  • To identify potential miRNA biomarkers for colon cancer diagnosis and therapy.

Summary:

  • A study analyzed miRNA expression in 3 pairs of colon adenocarcinoma and adjacent non-tumorous tissues using miRNA microarray and qRT-PCR.
  • Significant differential expression was observed, with 80 miRNAs showing a >2-fold change.
  • Specifically, 27 miRNAs were down-regulated and 2 were up-regulated in tumors (P<0.05), with qRT-PCR confirming microarray findings.

Impact:

  • The identified differentially expressed miRNAs may be involved in colon cancer carcinogenesis and progression.
  • miRNA expression profiles could serve as valuable molecular biomarkers for diagnosing colon adenocarcinoma.
  • These miRNAs represent potential therapeutic targets for colon cancer treatment.

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