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Updated: Jun 8, 2026
06:56
Characterization of Synthetic Polymers via Matrix Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) Mass Spectrometry
Published on: June 10, 2018
[The spectroscopy analysis of intermolecular interaction between the template molecule and functional monomer before
Xiao-ying Yin1, You-quan Zhong, Yi-fan Jiang
1Jiangxi University of Traditional Chinese Medicine College of Pharmacy, Nanchang 330004, China. ncyxoy@163.com
Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
|October 14, 2010
Summary
Researchers studied the interaction between andrographolide and acrylamide (AM) using spectroscopy. Stronger hydrogen bonds between these molecules in acetonitrile enhance the adsorption properties of molecularly imprinted polymers (MIPs).
Area of Science:
- Polymer Chemistry
- Spectroscopy
- Materials Science
Context:
- Developing non-covalent molecularly imprinted polymers (MIPs) requires understanding template-monomer interactions.
- Previous research on these specific interactions is limited.
- Optimizing MIPs for selective adsorption necessitates quantifying intermolecular forces.
Purpose:
- To investigate the intermolecular interactions between andrographolide (template) and acrylamide (AM, functional monomer).
- To utilize UV-Vis and infrared (IR) spectroscopy to analyze these interactions in different solvents.
- To correlate the degree of intermolecular interaction with the potential adsorption properties of resulting MIPs.
Summary:
- UV-Vis spectroscopy showed a 5 nm blue-shift in andrographolide's absorption peak and increased absorption in acetonitrile, indicating strong interaction with AM.
- IR spectroscopy revealed blue-shifts in O-H (8 cm⁻¹) and N-H (6 cm⁻¹) stretching vibrations, confirming strong hydrogen bonding between andrographolide and AM.
- Intermolecular interactions were significantly weaker in tetrahydrofuran and ethyl acetate compared to acetonitrile.
Impact:
- Demonstrates that strong intermolecular interactions, specifically blue-shifted hydrogen bonds, between template and functional monomer are crucial for MIP performance.
- Highlights acetonitrile as a suitable solvent for creating MIPs with andrographolide and AM due to enhanced interaction.
- Suggests that spectroscopy-based analysis of intermolecular interactions can predict and optimize the selectivity and adsorption capabilities of MIPs.
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