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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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Published on: May 22, 2018

PICMI: mapping point mutations on genomes.

Loredana Le Pera¹, Paolo Marcatili, Anna Tramontano

¹Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro, 5-00185 Rome, Italy.

Bioinformatics (Oxford, England)

|October 14, 2010

Summary

Mapping genomic variations is challenging. The PICMI server simplifies this by quickly locating amino acid or nucleotide variations on genomes and their gene products, including alternatively spliced isoforms.

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Area of Science:

Genomics
Bioinformatics

Background:

Increasing genomic variation data from international and local projects complements existing collections.
Genomic variation data is becoming relevant to a broader audience, including clinical researchers.
Mapping variations to genomes and identifying effects on gene isoforms is a complex task.

Purpose of the Study:

To develop a user-friendly tool for mapping genomic variations.
To facilitate the analysis of variations across different gene isoforms.

Main Methods:

Development of the PICMI server.
Implementation of algorithms for mapping amino acid and nucleotide variations.

Main Results:

The PICMI server enables rapid mapping of variations.
The tool accurately identifies variations on genomes and their products, including alternatively spliced isoforms.

Conclusions:

PICMI provides an efficient solution for analyzing genomic variations.
The server aids researchers in understanding the impact of variations on gene products.