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Updated: Jun 8, 2026
06:32
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
[Granulocytic sarcoma of the prostate]
Masahiro Nitta1, Akio Hoshi, Tetsuo Shinozaki
1The Department of Urology, Tokai University School of Medicine.
Hinyokika Kiyo. Acta Urologica Japonica
|October 14, 2010
Summary
Granulocytic sarcoma, a rare leukemia manifestation, can present as a prostate mass. This case highlights its initial presentation and subsequent development of acute myeloid leukemia.
Area of Science:
- Oncology
- Hematology
Background:
- Granulocytic sarcoma is an extramedullary tumor of myeloblasts.
- It can precede or coincide with acute myeloid leukemia.
- Prostate involvement is rare.
Observation:
- A 71-year-old man presented with dysuria and an elevated prostate-specific antigen level.
- A prostate biopsy revealed leukemia-like cells, but bone marrow examination was negative for malignancy.
- Imaging confirmed no other lesions, leading to a diagnosis of granulocytic sarcoma of the prostate.
Findings:
- Treatment with radiotherapy (40 Gy) improved dysuria and reduced prostate volume.
- Four months later, the patient developed acute myeloid leukemia (M2 subtype).
- The patient achieved remission after induction chemotherapy but relapsed 20 months later.
Implications:
- This case underscores the importance of considering granulocytic sarcoma in the differential diagnosis of prostate masses, especially with atypical presentations.
- Early recognition and appropriate management are crucial, as it can be a precursor to acute myeloid leukemia.
- The management of granulocytic sarcoma requires a multidisciplinary approach involving oncologists and hematologists.
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