Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...

Type I Diabetes III: Clinical Manifestations

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Characterization of Trimmed Nerve Morphology Using High-Resolution Imaging: Comparison of Three Surgical Instruments.

Journal of hand surgery global online·2026

Same author

Peer Review in Upper-Extremity Surgery: Essential Strategies for Reviewers.

The Journal of hand surgery·2026

Same author

Forearm Extensor Tendon Fractional Lengthening: An Anatomic Feasibility Study.

The Journal of hand surgery·2025

Same author

More Than Epineurium Deep: Characterizing Peripheral Nerve Damage Using High-Resolution Micro-Computed Tomography for Simulated Peripheral Nerve Lacerations.

Journal of hand surgery global online·2025

Same author

Recent trends in hand surgery fellowship applicants and programs.

Surgery in practice and science·2025

Same author

Safety of dorsal screw penetration at the proximal holes of volar locking plates.

Hand surgery & rehabilitation·2024

Search research articles

Related Experiment Video

Updated: Jun 8, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

[Hand disorders in diabetic patients].

Eitan Melamed¹, Shaul Goldstein, David Angel

¹Hand Unit, Department of Orthopaedic Surgery, Bnai-Zion Medical Center, Haifa, Israel. eitanme2000@yahoo.com

|October 15, 2010

Summary

Diabetic patients experience common hand disorders like trigger finger and carpal tunnel syndrome four times more often. This review covers their unique aspects and treatment outcomes in diabetes.

Area of Science:

Hand surgery
Diabetology
Musculoskeletal disorders

Context:

Diabetes mellitus significantly increases the prevalence of specific hand conditions.
Conditions like trigger finger, carpal tunnel syndrome, and Dupuytren's contracture are up to four times more common in diabetic individuals.
Limited joint mobility is another hand complication observed in diabetic patients.

Purpose:

To review the epidemiologic characteristics of common hand disorders in diabetic patients.
To discuss therapeutic considerations and treatment outcomes for these hand conditions in the context of diabetes.
To highlight differences in natural history and treatment response compared to the general population.

Summary:

Diabetic patients exhibit a higher incidence of trigger finger, carpal tunnel syndrome, and Dupuytren's contracture.

Related Experiment Videos

Last Updated: Jun 8, 2026

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Effects of Mindfulness Training Combined with Tai Chi in Patients with Diabetic Peripheral Neuropathy

Published on: July 14, 2023

The course and treatment effectiveness of these hand disorders may differ in individuals with diabetes.

Hand problems, including limited joint mobility, are a recognized complication of diabetes.

Impact:

Provides essential insights for clinicians managing hand disorders in diabetic patients.
Highlights the need for tailored treatment strategies considering the diabetic context.
Emphasizes the impact of diabetic hand complications on patient quality of life and activity.