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Physiologically based pharmacokinetic modeling of nanoparticles.

Mingguang Li1, Khuloud T Al-Jamal, Kostas Kostarelos

  • 1Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48202, United States.

ACS Nano
|October 16, 2010
PubMed
Summary

Physiologically based pharmacokinetic (PBPK) models can aid nanoparticle research by improving data interpretation and rational design. Modifications to PBPK models are necessary to accurately assess nanoparticle absorption, distribution, metabolism, and excretion (ADME).

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