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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
The interface between veterinary and human antibiotic use
Thomas R Shryock1, Amy Richwine
1Department of Research and Development, Elanco Animal Health, Greenfield, Indiana 46140, USA. thomas.r.shryock73@lilly.com
Annals of the New York Academy of Sciences
|October 16, 2010
Summary
Developing new veterinary antimicrobials faces challenges similar to human medicine. Growing concerns about antimicrobial resistance in humans, especially from foodborne pathogens, are shifting industry focus toward safer veterinary drug development.
Area of Science:
- Veterinary Pharmacology
- Antimicrobial Resistance
- Food Safety
Background:
- Veterinary antimicrobial development shares challenges with human medicine.
- Shared antimicrobial classes between human and veterinary medicine raise concerns.
- Non-human use of antimicrobials may contribute to human antimicrobial resistance.
Purpose of the Study:
- To explore the challenges in developing novel antimicrobial agents for veterinary medicine.
- To address the growing concerns regarding antimicrobial resistance (AMR) in human pathogens linked to veterinary use.
- To examine the impact of AMR concerns on the veterinary pharmaceutical industry pipeline.
Main Methods:
- Literature review on veterinary antimicrobial development challenges.
- Analysis of stakeholder concerns regarding shared antimicrobial classes.
- Examination of the influence of foodborne disease resistance on industry trends.
Main Results:
- Similar business and technical hurdles exist for both human and veterinary antimicrobial development.
- Increased stakeholder awareness highlights the link between veterinary antimicrobial use and human AMR, particularly for foodborne pathogens like Salmonella and Campylobacter.
- Industry pipeline for novel veterinary antimicrobials is being redirected due to AMR concerns.
Conclusions:
- The development of veterinary antimicrobials is intrinsically linked to human public health.
- Addressing antimicrobial resistance requires a One Health approach, considering both human and animal use.
- The pharmaceutical industry is adapting its strategy for veterinary antimicrobial development in response to AMR pressures.
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