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Published on: January 19, 2017

Prevalence and clinical implication of metabolic syndrome in chronic heart failure

Yutaka Miura1, Yoshihiro Fukumoto, Nobuyuki Shiba

  • 1Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

Circulation Journal : Official Journal of the Japanese Circulation Society
|October 19, 2010
PubMed

Insights

Metabolic syndrome (MetS) prevalence is double in chronic heart failure (CHF) patients compared to the general population. Metabolic components significantly impact both ischemic and non-ischemic CHF development.

Area of Science:

  • Cardiology
  • Metabolic Diseases
  • Public Health

Background:

  • Metabolic syndrome (MetS) is linked to ischemic heart disease (IHD).
  • Its prevalence and significance in chronic heart failure (CHF) require further investigation.

Purpose of the Study:

  • To determine the prevalence of MetS in Japanese patients with stage C/D CHF.
  • To analyze the clinical characteristics and contributing metabolic factors in CHF patients with MetS.

Main Methods:

  • A nationwide, large-scale clinical study involving 3,603 CHF patients from 6 Japanese institutes.
  • Analysis of demographic data, lifestyle factors, comorbidities, and metabolic components.

Main Results:

  • MetS prevalence in CHF patients was 45% in males and 19% in females, exceeding double that of the general population.
  • CHF patients with MetS were younger, more likely to smoke/drink, and had higher rates of IHD and hypertensive heart disease.
  • Elderly females with CHF showed a higher prevalence of heart failure with preserved ejection fraction and MetS.
  • Metabolic components contributed similarly to both ischemic and non-ischemic CHF.

Conclusions:

  • MetS is highly prevalent in Japanese CHF patients, significantly higher than in the general population.
  • Metabolic components play a substantial role in the development of both ischemic and non-ischemic CHF.
Abstract

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