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Updated: Jun 8, 2026

Fluorescence detection methods for microfluidic droplet platforms
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Published on: December 10, 2011

Plasmon-controlled fluorescence: A new detection technology.

Joseph R Lakowicz1, Mustafa H Chowdhury, Krishanu Ray

  • 1Center for Fluorescence Spectroscopy, University of Maryland at Baltimore, Department of Biochemistry and Molecular Biology, 725 West Lombard Street, Baltimore, MD 21201.

Proceedings of Spie--The International Society for Optical Engineering
|October 19, 2010
PubMed
Summary
This summary is machine-generated.

Plasmon-controlled fluorescence combines plasmonics and nanofabrication to enhance fluorescence technology. This novel approach controls fluorophore emission, promising new probes and devices for biology and medicine.

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Detection of CD40 Protein-Umbelliferone Interaction via Differential Scanning Fluorescence
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Area of Science:

  • Optics and Photonics
  • Nanotechnology
  • Biophysics

Background:

  • Fluorescence is a cornerstone of biological research, with advancements crucial for progress in biology and medicine.
  • Current fluorescence technology has limitations that can be overcome by integrating plasmonics and nanofabrication.

Purpose of the Study:

  • To explore how combining fluorescence, plasmonics, and nanofabrication can revolutionize fluorescence measurement capabilities.
  • To introduce and define the concept of plasmon-controlled fluorescence (PCF).

Main Methods:

  • Utilizing surface plasmons, which are collective electron oscillations in metallic nanostructures.
  • Investigating the interaction between fluorophores (in ground and excited states) and surface plasmons.
  • Leveraging the optical properties of metallic nanostructures to control fluorescence.

Main Results:

  • Demonstrated that fluorophores can generate surface plasmons and interact with them for excitation.
  • Showcased that metallic nanostructures can control fluorescence decay rates, emission location, and direction.
  • Established the foundation for plasmon-controlled fluorescence (PCF) technology.

Conclusions:

  • Plasmon-controlled fluorescence (PCF) represents a significant advancement in fluorescence technology.
  • PCF enables the design of enhanced fluorescent probes and novel devices for energy control and conversion.
  • This technology is poised to drive a new generation of bio-imaging and diagnostic tools.