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Regulation of xenogeneic porcine pancreatic islets

Judith A Arcidiacono1, Evgenij Evdokimov, Mark H Lee

  • 1FDA, Center for Biologics Evaluation and Research (CBER), Office of Cellular, Tissue and Gene Therapies, Rockville, MD 20852, USA.

Xenotransplantation
|October 20, 2010
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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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